Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
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چکیده
منابع مشابه
Stable Cellular Senescence Is Associated with Persistent DDR Activation
The DNA damage response (DDR) is activated upon DNA damage generation to promote DNA repair and inhibit cell cycle progression in the presence of a lesion. Cellular senescence is a permanent cell cycle arrest characterized by persistent DDR activation. However, some reports suggest that DDR activation is a feature only of early cellular senescence that is then lost with time. This challenges th...
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ژورنال
عنوان ژورنال: BMC Cell Biology
سال: 2017
ISSN: 1471-2121
DOI: 10.1186/s12860-017-0147-7